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Apcalis and Regalis are generic drugs for Cialis. It comes as light yellow, almond-shaped film-coated tablets. These tablets are available in blister packs containing 2 tablets. Apcalis is a treatment for men with erectile dysfunction. This is when a man cannot get, or keep a hard, erect penis suitable for sexual activity. Generic Cialis belongs to a group of medicines called phosphodiesterase type 5 inhibitors. Following sexual stimulation Regalis works by helping the blood vessels in your penis to relax, allowing the flow of blood into your penis. The result of this is improved erectile function. This medicine will not help you if you do not have erectile dysfunction. It is important to note that it does not work if there is no sexual stimulation. You and your partner will need to engage in foreplay, just as you would if you were not taking a medicine for erectile dysfunction.
How does Apcalis (Tadalafil) work?
In technical terms APCALIS exerts its action by effecting two enzymes, Cyclic guanosine monophosphate (cGMP) and phosphodiesterase type 5 (PDE5) that play important roles in erectile function. Sexual stimulation triggers the local release of nitric oxide (NO) from nerves and endothelial cells in the penis. NO stimulates an enzyme that catalyzes formation of cGMP from the nucleotide guanosine 5-triphospate (GTP) in the penile blood vessels and corpus cavernosum walls. The cGMP causes vasodilation of arteries, allowing the influx of blood into the corpus cavernosum. Increased blood flow into the penis causes the erectile tissue to expand. When the erectile tissue has expanded sufficiently, the veins draining the corpus cavernosum become compressed. This decreases the outflow of blood from the penis, and the blood remains in the corpus cavernosum to keep the penis erect. The enzyme PDE5 eventually causes degradation of the cGMP, and the erection ends.
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